Cannabinoid

Globalresearchemvendor.com is a reliable provider of top of the line substance arrangements. In the event that you are scanning for the best decision of manufactured concoction mixes, look no more distant than our online research synthetic store. We give a tremendous combination of superb engineered substances, including cannabinoids. Restorative and instructive organizations, pharmaceutical researchers, labs, and natural chemists are among our normal customers. Science sweethearts and understudies who require propelled compound answers for studies and tests inside qualified logical research or science graduate projects can likewise profit by our items. Our online shop is the ideal place for people who need to purchase cannabinoid items at sensible costs in only a couple of snaps.

What makes us stand separated from the various cannabinoid online stores is the way that we move cannabinoids both discount and retail. When obtaining synthetic arrangements from us, you can settle on the amount of the required concoction compound. You can pick between the accompanying amount alternatives:

10 grams

25 grams

50 grams

100 grams

250 grams

500 grams

1 kg

Regardless of whether you arrange 10, 100 or 500 grams of a substance for your cannabinoid inquire about, you can rest guaranteed you will get a lot. We can vouch for the nature of all cannabinoid items exhibited in our online index.

Purchase engineered cannabinoids online without medicine

At First Trust Chemicals, you can purchase cannabinoid substances without a remedy. The main thing you have to do is select the kind of cannabinoid you need to purchase, add it to truck and pay for it. We acknowledge diverse installment choices, including Western Union and MoneyGram, Bank Transfer, WebMoney Transfer and Bitcoins. Additionally, we offer diverse conveyance alternatives. You can pick between mail station, standard, express and same day conveyance shipping choices. Worth referencing that delivery cost additionally relies upon the general load of your bundle.

Try not to squander your valuable time in the various cannabinoid online stores — investigate the huge choice of cannabinoid items available to be purchased we supply.

Look at the full combination of cannabinoid supplements available to be purchased we stock in USA

Cannabinoids are normally happening mixes found in the Cannabis sativa plant. Despite the fact that there are more than 500 different mixes present in the plant, just around 70 are named cannabinoids. Different plants likewise create cannabinoids, yet not to indistinguishable degree from cannabis or hemp do. At our store, you can purchase such kinds of cannabinoid substances as AB-FUBINACA, AM-2201, and DEX POWDER. Cannabinoids we supply are engineered aggravates that are normally depicted as human-made synthetic concoctions showered on dried plant material.

Another favorable position of acquiring cannabinoid items from us is that we move brilliant substance arrangements at reasonable costs. Here, you can purchase 10 grams of AB-FUBINACA for 115.00$ as it were. While the cost for 10 grams of DEX powder is 125.00$.

Purchase cannabinoid supplements at Globalresearchemvendor.comand get sensible rebate rates. The more you arrange, the more rebate you will get.

Globalresearchemvendor.com is a reliable provider of top of the line substance arrangements. In the event that you are scanning for the best decision of manufactured concoction mixes, look no more distant than our online research synthetic store. We give a tremendous combination of superb engineered substances, including cannabinoids. Restorative and instructive organizations, pharmaceutical researchers, labs, and natural chemists are among our normal customers. Science sweethearts and understudies who require propelled compound answers for studies and tests inside qualified logical research or science graduate projects can likewise profit by our items. Our online shop is the ideal place for people who need to purchase cannabinoid items at sensible costs in only a couple of snaps.

What makes us stand separated from the various cannabinoid online stores is the way that we move cannabinoids both discount and retail. When obtaining synthetic arrangements from us, you can settle on the amount of the required concoction compound. You can pick between the accompanying amount alternatives:

10 grams

25 grams

50 grams

100 grams

250 grams

500 grams

1 kg

Regardless of whether you arrange 10, 100 or 500 grams of a substance for your cannabinoid inquire about, you can rest guaranteed you will get a lot. We can vouch for the nature of all cannabinoid items exhibited in our online index.

Purchase engineered cannabinoids online without medicine

At First Trust Chemicals, you can purchase cannabinoid substances without a remedy. The main thing you have to do is select the kind of cannabinoid you need to purchase, add it to truck and pay for it. We acknowledge diverse installment choices, including Western Union and MoneyGram, Bank Transfer, WebMoney Transfer and Bitcoins. Additionally, we offer diverse conveyance alternatives. You can pick between mail station, standard, express and same day conveyance shipping choices. Worth referencing that delivery cost additionally relies upon the general load of your bundle.

Try not to squander your valuable time in the various cannabinoid online stores — investigate the huge choice of cannabinoid items available to be purchased we supply.

Look at the full combination of cannabinoid supplements available to be purchased we stock in USA

Cannabinoids are normally happening mixes found in the Cannabis sativa plant. Despite the fact that there are more than 500 different mixes present in the plant, just around 70 are named cannabinoids. Different plants likewise create cannabinoids, yet not to indistinguishable degree from cannabis or hemp do. At our store, you can purchase such kinds of cannabinoid substances as AB-FUBINACA, AM-2201, and DEX POWDER. Cannabinoids we supply are engineered aggravates that are normally depicted as human-made synthetic concoctions showered on dried plant material.

Another favorable position of acquiring cannabinoid items from us is that we move brilliant substance arrangements at reasonable costs. Here, you can purchase 10 grams of AB-FUBINACA for 115.00$ as it were. While the cost for 10 grams of DEX powder is 125.00$.

Purchase cannabinoid supplements at Globalresearchemvendor.comand get sensible rebate rates. The more you arrange, the more rebate you will get.

Globalresearchemvendor.com is a reliable provider of top of the line substance arrangements. In the event that you are scanning for the best decision of manufactured concoction mixes, look no more distant than our online research synthetic store. We give a tremendous combination of superb engineered substances, including cannabinoids. Restorative and instructive organizations, pharmaceutical researchers, labs, and natural chemists are among our normal customers. Science sweethearts and understudies who require propelled compound answers for studies and tests inside qualified logical research or science graduate projects can likewise profit by our items. Our online shop is the ideal place for people who need to purchase cannabinoid items at sensible costs in only a couple of snaps.

What makes us stand separated from the various cannabinoid online stores is the way that we move cannabinoids both discount and retail. When obtaining synthetic arrangements from us, you can settle on the amount of the required concoction compound. You can pick between the accompanying amount alternatives:

10 grams

25 grams

50 grams

100 grams

250 grams

500 grams

1 kg

Regardless of whether you arrange 10, 100 or 500 grams of a substance for your cannabinoid inquire about, you can rest guaranteed you will get a lot. We can vouch for the nature of all cannabinoid items exhibited in our online index.

Purchase engineered cannabinoids online without medicine

At First Trust Chemicals, you can purchase cannabinoid substances without a remedy. The main thing you have to do is select the kind of cannabinoid you need to purchase, add it to truck and pay for it. We acknowledge diverse installment choices, including Western Union and MoneyGram, Bank Transfer, WebMoney Transfer and Bitcoins. Additionally, we offer diverse conveyance alternatives. You can pick between mail station, standard, express and same day conveyance shipping choices. Worth referencing that delivery cost additionally relies upon the general load of your bundle.

Try not to squander your valuable time in the various cannabinoid online stores — investigate the huge choice of cannabinoid items available to be purchased we supply.

Look at the full combination of cannabinoid supplements available to be purchased we stock in USA

Cannabinoids are normally happening mixes found in the Cannabis sativa plant. Despite the fact that there are more than 500 different mixes present in the plant, just around 70 are named cannabinoids. Different plants likewise create cannabinoids, yet not to indistinguishable degree from cannabis or hemp do. At our store, you can purchase such kinds of cannabinoid substances as AB-FUBINACA, AM-2201, and DEX POWDER. Cannabinoids we supply are engineered aggravates that are normally depicted as human-made synthetic concoctions showered on dried plant material.

Another favorable position of acquiring cannabinoid items from us is that we move brilliant substance arrangements at reasonable costs. Here, you can purchase 10 grams of AB-FUBINACA for 115.00$ as it were. While the cost for 10 grams of DEX powder is 125.00$.

Purchase cannabinoid supplements at Globalresearchemvendor.comand get sensible rebate rates. The more you arrange, the more rebate you will get.

  • Sale!
    Codeine Phosphate 15mg Pills
    110.003,000.00
    2-AI
    110.003,000.00

    The cognitive effects of 2-AI can be broken down into several components which progressively intensify proportional to dosage. The general head space of 2-AI is described by many as one of mental stimulation, increased focus, and euphoria. It contains a large number of typical stimulant cognitive effects. Although negative side effects are usually mild at low to moderate doses, they become increasingly likely to manifest themselves with higher amounts or extended usage. This particularly holds true during the offset of the experience. The most prominent of these cognitive effects generally include:

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    Butyrfentanyl
    110.003,000.00
    2-AIMP
    110.003,000.00

    5-methoxy Methylone (also known as 2-A1MP and βk-MMDMA) is a cathinone derivative that bears a methoxy group similar to various tryptamine analogs including 5-methoxy MiPT, which are known to potently inhibit monoamine transport function.

    5-methoxy Methylone is a cathinone derivative that bears a methoxy group.

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    Butyrfentanyl
    110.003,000.00
    3FPM
    110.003,000.00

    It seems that phenmetrazine can give a false positive to screening (Amphetamine) But normally 3-FPM will metabolize in the body into a substance that has nothing to do with amphetamine. In any case the substance will not be recoverable in your urine after 3 to 5 days.

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    Butyrfentanyl
    110.003,000.00
    4-ACO-DMT POWDER
    110.003,000.00

    An O-acetylated psilocin that is believed to be a synthetic prodrug of psilocin, the psychedelic hallucinogen derived from various mushrooms; intended for forensic and research applications
    4-acetoxy DMT is an O-acetylated psilocin that is believed to be a synthetic prodrug of psilocin, the psychedelic hallucinogen derived from various mushrooms. Although its pharmacological and toxicological properties are not well known, its activity has been proposed to be somewhat similar to that of psilocybin and psilocin. This product is intended for forensic and research applications.

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    Butyrfentanyl
    110.003,000.00
    4-CMC CRYSTAL
    110.003,000.00

    4-CMC Crystals drawn into the nose begins to run fine of 100 mg. It is not recommended to exceed the dose above 180 mg. Terribly bakes in the nose for a few minutes after being pulled. Operation is much shorter and is about one hour. There is quite a strong desire for further tightening strokes. The effect of stimulation of the way the administration is already very clear. Unfortunately, stimulation does not go hand in hand with concentration. There are problems with concentration, speech may be tangled, a rapid heartbeat, sweating, chills, nausea. Euphoria is more comparable to the popular mephedrone and initial results are similar to it. Pleasant phase is often intertwined with something that researchers call “light struciem.”

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    Butyrfentanyl
    110.003,000.00
    4-FMPH
    110.003,000.00

    4F-MPH is a new research chemical in the stimulant family with an IUPAC name methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate. The chemical formula for 4F-MPH is C14H18FNO2 and it has a molecular weight of 251.30. The CAS number is 1354631-336. The chemical is so new on the market we must look research performed on its analog with is 4-MPH.

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    Butyrfentanyl
    110.003,000.00
    4-MPD
    110.003,000.00

    4-Methylpentedrone, is a stimulant drug of the cathinone class that has been sold online as a designer drug. It is a higher homologue of 4-Methylmethcathinone and 4-Methylbuphedrone, and the p-Methyl analogue of Pentedrone.

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    Butyrfentanyl
    110.003,000.00
    5-fur-144
    110.003,000.00

    XLR-11 (5″ – fluoro-UR-144) a chemical compound which allegedly works as an agonist to kannabinoidny receptors. Is a derivative indole 2-(chetyrekhmetilny-tsiklopropiletanol), the connection relating to such as: UR-144, A-796,260 and A-834,735, but is not brought in the patent or scientific literature together with these similar connections. It was made by the Abbott Laboratories company, despite existence of the patent application of WO 2006/069196. XLR-11 was for the first time defined by laboratories in 2012 as ingredient of mixes of synthetic marijuana for smoking, and became the new connection relating to “design drugs”. It is forbidden in New Zealand and entered in the list of narcotic connections since July 13, 2012. It is also  in Florida since December 11, 2012.

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    Butyrfentanyl
    110.003,000.00
    5F-AKB48
    110.003,000.00

    UB – AKB48 which in the chemical nomenclature is also known as F5-APINICA is an indazole- constituted synthetic designer cannabinoid and it is also considered to be a strong agonist for receptors like CB1 and CB2. We supply in bulk and small order starting as low as 25 grams .

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    Butyrfentanyl
    110.003,000.00
    5F-MN24
    110.003,000.00

    5F-NNE1 (also known as 5F-NNEI and 5F-MN-24) is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online as a designer drug.[1][2] Given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, it is suspected that metabolic hydrolysis of the amide group of 5F-NNE1 may release 1-naphthylamine, a known carcinogen.

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    AB-FUBINACA
    115.001,300.00
    AB-FUBINACA
    115.001,300.00
    AB-FUBINACA is a drug that acts as a potent agonist for the cannabinoid receptors, with Kᵢ values of 0.9 nM at CB₁ and 23.2 nM at CB₂,
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    Butyrfentanyl
    110.003,000.00
    AB-PINACA
    110.003,000.00

    AB-PINACA is a synthetic cannabinoid usually sold as a herbal smoking mixture designed to mimic THC, the active chemical of cannabAis. Synthetic cannabinoids are classed as ‘New Psychoactive Substances’ (NPS) which are unregulated substances that have become newly available on the market as an alternative to illegal drugs. As a reaction to prohibition, synthetic cannabinoid producers change the compounds found in designer drugs and create new generations of synthetic drugs, such as AB-PINACA. As a result, accidental overdose and severe psychiatric complications may be more likely to occur because the type and amount of active compound may vary considerably from batch to batch. Other effects may include agitation, rapid heart rate, confusion, dizziness and nausea.

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    Butyrfentanyl
    110.003,000.00
    AM-2201
    110.003,000.00

    The clinical effects of most new designer drugs like AM-2201 can be described as either hallucinogenic, stimulant, or opioid-like. They may also have a combination of these effects due to designer side-chain substitutions.

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    Butyrfentanyl
    110.003,000.00
    BK-EBDP
    110.003,000.00

    BK-EDBP, 4-cec, 4-cdc, DIBU (dibutylone), Isopropylphenidatehttp://globalresearchemvendor.com, appp, 4f-php, adbf, hex-en, fub-amb, 3FPM, 5FADB, MK-677, APPP, 4FPHP, mmbc, mdphp, 4cl-pvp, phpp, ej018, nm2201, 4f-mph, mdph, PMK, BMK powder, sildenafil , Tadafil, Viagra, HGH, lidocaine ,benzocaine , etc…

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    Butyrfentanyl
    110.003,000.00
    Dibutylone 
    110.003,000.00

    Dibutylone acts as a psychedelic drug that can provide stimulation to user. You will find instant relief from any mental pressure that you are in . And will experience a level of clarity of mind that you would never have experienced before. It is similar with Butylone. However,Butylone is illegal in most parts of the world but Dibutylone not. Dibutylone is nearly legal all over the world.

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    Butyrfentanyl
    110.003,000.00
    FAB-144
    110.003,000.00

    FAB-144 is an indazole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online as a designer drug.[1] It is the indazole analogue of XLR-11. FAB-144 is an analogue of XLR-11, which acts like a potent agonist for the cannbinoid receptors. The CB1 and CB2 receptors offer a Ki of 24.2nM along with an EC50 of 359nM at CB1. It is an indole derivate, which is related to other compound including A-834,735 and A-796,260.

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    Butyrfentanyl
    110.003,000.00
    FUB-AMB
    110.003,000.00

    MMB-FUBINACA (FUB-AMB; Item No. 9001960) is an analytical reference standard that is structurally classified as a synthetic cannabinoid. It is the methyl ester analog of AB-FUBINACA (Item No. 14039), where the terminal amide group of the valine has been replaced with a methyl ester. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.

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    Butyrfentanyl
    110.003,000.00
    FUB-PB22
    110.003,000.00

    A presumptive metabolite of FUB-PB-22
    FUB-PB-22 3-carboxyindole metabolite is an analytical reference material that is structurally classified as a synthetic cannabinoid. It is a presumptive metabolite of FUB-PB-22

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    Butyrfentanyl
    110.003,000.00
    JWH-122
    110.003,000.00
    A certified solution standard suitable for use as starting material in calibrators and controls for GC/MS or LC/MS synthetic cannabinoid testing methods in forensic analysis, clinical toxicology, or urine drug testing. This monohydroxy analog is a primary urinary metabolite of JWH-122, a synthetic cannabinoid found in blends of the herbal mixture K2 or Spice. This biomarker is also referred to as the terminal omega hydroxy metabolite of JWH-122.
    For those synthetic cannabinoids currently controlled at the federal level, our certified solution standards of these substances are DEA-exempt, allowing laboratories to place orders without additional regulatory paperwork. For US customers, state specific regulatory requirements may apply.
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    Butyrfentanyl
    110.003,000.00
    JWH-210
    110.003,000.00

    Synthetic cannabinoids JWH-018 and JWH-250 in ‘herbal incense’ also called ‘spice’ were first introduced in many countries. Numerous synthetic cannabinoids with similar chemical structures emerged simultaneously and suddenly. Currently there are not sufficient data on their adverse effects including neurotoxicity. There are only anecdotal reports that suggest their toxicity. In the present study, we evaluated the neurotoxicity of two synthetic cannabinoids (JWH-081 and JWH-210) through observation of various behavioral changes and analysis of histopathological changes using experimental mice with various doses (0.1, 1, 5 mg/kg). In functional observation battery (FOB) test, animals treated with 5 mg/kg of JWH-081 or JWH-210 showed traction and tremor.

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    Butyrfentanyl
    110.003,000.00
    JWH-307
    110.003,000.00

    JWH-307 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB2 subtype, with a Ki of 7.7nM at CB1 vs 3.3nM at CB2. It was discovered by, and named after, Dr. John W. Huffman. JWH-307 was detected as an ingredient in synthetic cannabis smoking blends in 2012

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    AB-FUBINACA
    110.003,000.00
    ketamine HCL
    110.003,000.00

    Ketamine hydrochloride is clinically compatible with the commonly used general and local anesthetic agents when an adequate respiratory exchange is maintained.

    The regimen of a reduced dose of ketamine hydrochloride supplemented with diazepam can be used to produce balanced anesthesia by combination with other agents such as nitrous oxide and oxygen.

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    Butyrfentanyl
    110.003,000.00
    MAM-2201
    110.003,000.00

    The reduction of neurotransmitter release from CB1R-containing synapses could contribute to some of the symptoms of synthetic cannabinoid intoxication including impairments in cerebellum-dependent motor coordination and motor learning.

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    Butyrfentanyl
    110.003,000.00
    MMBC
    110.003,000.00

    Mephedrone, also known as 4-methyl methcathinone or 4-methyl ephedrone, is a synthetic stimulant drug of the amphetamine and cathinone classes. Slang names include bath salts, drone, M-CAT, White Magic and meow meow. It is chemically similar to the cathinone compounds found in the khat plant of eastern Africa.

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    2-fa
    110.003,000.00
    MPHP
    110.003,000.00

    The respective 4′-carboxy metabolite of pyrovalerone was found to be inactive in vivo [30]. A recently published case report by Sauer et al. of acute poisoning due to MPHP further supports the assumption of similar metabolic pathways as only the 4′-carboxy metabolite was detected in urine samples of the patient [39]. In consideration of their structural similarity to pyrovalerone, the 4′-hydroxymethyl metabolites of MPPP, MPBP and MPHP can also be expected to be pharmacologically active. …

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    AB-FUBINACA
    110.003,000.00
    NM-2201
    110.003,000.00

    NM-2201 (also known as CBL-2201) is an indole-based synthetic cannabinoid that is presumably a full agonist and unselectively binds to CB1 and CB2 receptors with low nanomolar affinity, the potent synthetic cannabinoid (CB) with Ki values of 1.0 and 2.6 nM for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, respectively. Little to no research data available on this chemical makes it impossible to describe it’s properties in detail.
    NM-2201 is a synthetic cannabinoid is similar in structure to AM-2201, differing by an ester linking the 3’ position to the naphthyl group. This drug was discovered by Alexandros Makriyannis from Northeastern University.The physiological and toxicological properties of this compound are not currently known.This product is intended for forensic and research applications.

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    Butyrfentanyl
    110.003,000.00
    PB-22
    110.003,000.00

    5F-PB-22, or quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate, is a synthetic indole cannabinoid as it contains a substituted core indole structure. This indole core is shared with other cannabinoid substances including PB-22JWH-018, and AM2201. 5F-PB-22 is an ether with formula R-O-R’, which can be understood as a substance with two sub-units joined through an oxygen bridge. The indole group of 5F-PB-22 is substituted at R5 with a fluoropentyl chain, a substitution shared with 5F-AKB48. Additionally, the indole core is substituted at R3 with a carboxylic acid group. The terminal oxygen of this carboxylic acid is bonded through an ether bond to a quinoline group at location R8 of the heterocycle.

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    Valium Diazepam Pills
    110.003,000.00
    PSEUDOEPHEDRINE HCL
    110.003,000.00

    The formulation of pseudoephedrine Hydrochloride (HCl) extended release was prepared by using different polymers (HPMC and ethocel) and with different diluents (dibasic calcium phosphate anhydrous, dibasic calcium phosphate dihydrate, lactose anhydrous and DCL-15). The experimental work including preformulation studies, formulation development and evaluation. The results of the present study point out that the type and level of excipients influence the rate and extent of pseudoephedrine HCL extended release. The insoluble diluents especially dibasic calcium phosphate causes that the drug to be release at a slower rate and to lesser extent than the soluble diluents (lactose) was investigated. The effect of pseudo polymorphic form of dibasic calcium phosphate on the dissolution profile was studied. Analysis of dissolution profile on the basis of Higuchi’s model suggested that the drug release mechanism basically swelling and diffusion controlled.

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    Butyrfentanyl
    110.003,000.00
    SDB-005
    110.003,000.00

    SDB-005 is an indazole-based synthetic cannabinoid that has been sold online as a designer drug. It is presumed to be an agonist of the CB1 and CB2 cannabinoid receptors. SDB-005 is the indazole core analogue of PB-22 where the 8-hydroxyquinoline has also been replaced with a naphthalene group.

     

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    Butyrfentanyl
    110.003,000.00
    SDB-006
    110.003,000.00

    The present study aims to recommend appropriate marker metabolites for documenting SDB-006 consumption by investigating its metabolism in human hepatocytes. For metabolite profiling, 10 µM of SDB-006 was incubated in human hepatocytes for 3 h. Metabolite identification in hepatocyte samples was accomplished with high-resolution mass spectrometry via information-dependent data acquisition. Results revealed that SDB-006 was highly metabolized in human hepatocytes.

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    Butyrfentanyl
    120.003,000.00
    SGT-263
    120.003,000.00

    SGT-78 (also known as CUMYL-CYBINACA or CUMYL-4CN-BINACA ) is an indazole-3-carboxamide based synthetic cannabinoid that has been sold online as a designer drug.

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    Butyrfentanyl
    110.003,000.00
    TH-PBP
    110.003,000.00

    Human farnesyl pyrophosphate synthase (hFPPS) controls the post-translational prenylation of small GTPase proteins that are essential for cell signaling, cell proliferation, and osteoclast-mediated bone resorption. Inhibition of hFPPS is a clinically validated mechanism for the treatment of lytic bone diseases, including osteoporosis and cancer related bone metastases. A new series of thienopyrimidine-based bisphosphonates (ThP-BPs) were identified that inhibit hFPPS with low nanomolar potency. Crystallographic evidence revealed binding of ThP-BP inhibitors in the allylic subpocket of hFPPS. Simultaneous binding of inorganic pyrophosphate in the IPP subpocket leads to conformational closing of the active site cavity. The ThP-BP analogues are significantly less hydrophilic yet exhibit higher affinity for the bone mineral hydroxyapatite than the current N-BP drug risedronic acid. The antiproliferation properties of a potent ThB-BP analogue was assessed in a multiple myeloma cell line and found to be equipotent to the best current N-BP drugs. Consequently, these compounds represent a new structural class of hFPPS inhibitors and a novel scaffold for the development of human therapeutics.

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    Butyrfentanyl
    110.003,000.00
    THJ-2201
    110.003,000.00

    The widespread recreational use of synthetic cannabinoids (SCBs) represents a major public health issue, as reports of intoxications and deaths following SCB use rapidly mount up. Specifically, a direct link between SCB use and acute kidney injury (AKI) has been established, although the pathophysiologic mechanisms remain undefined. Here we assessed the in vitro nephrotoxicity of three commonly detected and structurally distinct SCBs – AB-FUBINACA, JWH-122 and THJ-2201 – in human proximal tubule cells (HK-2), to ascertain potential similarities and/or differences regarding their nephrotoxicity signatures. We showed that two of the three SCBs tested, namely JWH-122 and THJ-2201, at in vivo relevant concentrations (1 nM – 1 μM), triggered apoptotic cell death pathways, mainly through a shared mechanism involving the deregulation of mitochondrial function (i.e. with mitochondrial membrane hyperpolarization and increased intracellular ATP levels), as the primary molecular signature of nephrotoxicity mechanism.

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    AB-FUBINACA
    110.003,000.00
    U-47700
    110.003,000.00

    U-47700 is a synthetic opioid developed in the 1970s by the Michigan-based pharmaceutical manufacturing firm Upjohn. A chemical compound formed during research, U-47700 sat dormant for many years but has resurfaced on the streets. U-47700 is being sourced overseas from China and Eastern Europe. The painkiller is almost eight times stronger than morphine and is readily available, and affordable, online. U-47700’s extreme potency, and lack of government regulation, has health officials deeply concerned as overdoses rise.

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    Butyrfentanyl
    110.003,000.00
    UR-144
    110.003,000.00

    UR-144 is a synthetic cannabinoid of the tetramethylcyclopropyl series. Along with XLR-11, cyclopropyl Spice analogs have seen wide popularity in the illicit markets since late 2012. UR-144 was originally developed as a pharmaceutical drug candidate due to its high affinity for the cannabinoid receptor CB2.

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    Valium Diazepam Pills
    150.00750.00
    Valium Diazepam Pills
    150.00750.00
    Valium Diazepam Pills is a benzodiazepine derivative. The chemical name of diazepam is 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin- 2-one
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