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More recent research supports 5-MeO-MiPT primarily being a serotonin receptor agonist. It can activate 5-HT2A (shown by intracellular calcium increase) with an ED50 of 7.82 nM or 566 nM if looking at 5-HT2A beta-arrestin recruitment, which involves another signalling pathway (Blough, 2014). Blough (2014) showed it had no reuptake inhibition at SERT, NET, or DAT at up to 10 μM (10,000 nM).
Other studies have similarly shown the drug should be classified as a serotonin receptor agonist, much like other psychedelics (Ray, 2010; Rickli, 2016). The different effect profile, such as some entactogen-like mood states and tactile enhancement, doesn’t seem to be coming from monoamine release or reuptake inhibition.