5-MEO-MIPT

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110.002,750.00

More recent research supports 5-MeO-MiPT primarily being a serotonin receptor agonist. It can activate 5-HT2A (shown by intracellular calcium increase) with an ED50 of 7.82 nM or 566 nM if looking at 5-HT2A beta-arrestin recruitment, which involves another signalling pathway (Blough, 2014). Blough (2014) showed it had no reuptake inhibition at SERT, NET, or DAT at up to 10 μM (10,000 nM).

Other studies have similarly shown the drug should be classified as a serotonin receptor agonist, much like other psychedelics (Ray, 2010; Rickli, 2016). The different effect profile, such as some entactogen-like mood states and tactile enhancement, doesn’t seem to be coming from monoamine release or reuptake inhibition.

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Description

5-MeO-MiPT is a psychedelic in the tryptamine class. It’s uncommon relative to LSD and psilocin, but it has been used for a couple of decades. It’s not a very visual substance at common doses. Instead, it’s known for producing greater tactile, bodily, and sexual effects than other psychedelics.

It’s part of the research chemical market and has been sold as itself and as a component of branded products.


5-MeO-MiPT = 5-Methoxy-N-methyl-N-isopropyltryptamine; Moxy

PubChem: 2763156

Molecular formula:  C15H22N2O

Molecular weight: 246.354 g/mol

IUPAC: N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-methylpropan-2-amine

The dose-response curve is steep, meaning a small increase can yield a substantial change in intensity. A couple milligrams may be all it takes to make an experience unpleasant and overwhelming. Since the drug is quite potent and responses vary between people, users should be careful with their dosing and initially take a light amount to evaluate their response.

A scale is needed for proper dosing, though typical milligram scales still won’t be ideal for measuring. Therefore, a scale should be used alongside volumetric dosing.

While some people find under 10 mg to be underwhelming, others find the same amount or less to be very uncomfortable.

Doses under 10 mg may be preferred for mood effects and physical euphoria, while higher doses are more likely to offer notable psychedelic effects.

Sexual effects are attributed to the drug more often than with most psychedelics. Tactile enhancement combines with a higher sex drive and lower inhibition. It’s also easier for a male to get an erection than it is with entactogens, which also enhance tactile sensation. Orgasms can be more intense as well. Many reports describe sexual thoughts or sensations suddenly manifesting under the influence, even in situations that aren’t conducive to sexual activity. Those feelings can be ignored if needed and they don’t occur for everyone.

Music is often more impactful.  Users report noticing aspects of songs that are normally ignored and music may also trigger physical sensations or visual distortions, more often with eyes closed. Music and sex are two of the main cases where people, at least those who respond well to the drug, will choose it in place of other psychedelics. Actual auditory distortions can be present as well, though they’re not always positive.

Because it doesn’t have a significant headspace and usually doesn’t produce strong visuals, the tactile and other sensory effects are some of the main positive aspects of the drug. If those aren’t present or sufficiently enjoyable, you may be disappointed. But when the experience is positive it can be one of the most enjoyable psychedelics.

Body load is very common and can ruin the experience when it’s significant. It can include nausea, over-excitation, vomiting, chills, lightheadedness, bloating, shivering, sensations of heat, tension, and headache. Feeling like you can’t breathe properly or like you’re experiencing a lot of cardiovascular stress can contribute to anxiety and panic.

These physical symptoms underlie a lot of the anxiogenic potential of the drug and are responsible for a large portion of the negative experiences. In the absence of those properties it doesn’t tend to cause much anxiety on its own. People are much more likely to become stressed due to feeling uncomfortable and being concerned about their physical safety.

It’s not an exaggeration to say it can feel horrible to an extent that’s largely not seen with other psychedelics. This isn’t the typical experience, but it’s a possibility, and it’s one of the reasons you need to be careful with your dosing.

On average, the come up is more uncomfortable than the peak and comedown.

Despite it having a notable body load, it can also come with physical euphoria and other positive bodily effects, sometimes concurrently with the aforementioned negatives. Tactile enhancement, such as things feeling softer or enjoying contact with other people, is very common. And even in the absence of external input, it can produce rushes of pleasurable sensations in the body. This same effect might be the cause of unpleasant coldness and heat for those who are perceiving the effect differently.

 

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