FAB-144

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FAB-144 is an indazole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online as a designer drug.[1] It is the indazole analogue of XLR-11. FAB-144 is an analogue of XLR-11, which acts like a potent agonist for the cannbinoid receptors. The CB1 and CB2 receptors offer a Ki of 24.2nM along with an EC50 of 359nM at CB1. It is an indole derivate, which is related to other compound including A-834,735 and A-796,260.

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Description

FAB-144 is a synthetic cannabinoid (CB) with a tetramethylcyclopropyl group, which reportedly confers selectivity for the peripheral CB2receptor over the central CB1 receptor. FAB-144 is an analog of XLR11 that has an indazole, rather than an indole group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.

that acts as a potent agonist for the cannabinoid receptors CB and CB with EC values of 98 nM and 83 nM, respectively.[1] It is a 3-(tetramethylcyclopropylmethanoyl)indole derivative related to compounds such as UR-144, A-796,260 and A-834,735, but it is not specifically listed in the patent or scientific literature alongside these other similar compounds,[2][3] and appears to have not previously been made by Abbott Laboratories, despite falling within the claims of patent WO 2006/069196. XLR-11 was found to produce rapid, short-lived hypothermic effects in rats at doses of 3 mg/kg and 10 mg/kg, suggesting that it is of comparable potency to APICA and STS-135.

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