PSEUDOEPHEDRINE HCL

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The formulation of pseudoephedrine Hydrochloride (HCl) extended release was prepared by using different polymers (HPMC and ethocel) and with different diluents (dibasic calcium phosphate anhydrous, dibasic calcium phosphate dihydrate, lactose anhydrous and DCL-15). The experimental work including preformulation studies, formulation development and evaluation. The results of the present study point out that the type and level of excipients influence the rate and extent of pseudoephedrine HCL extended release. The insoluble diluents especially dibasic calcium phosphate causes that the drug to be release at a slower rate and to lesser extent than the soluble diluents (lactose) was investigated. The effect of pseudo polymorphic form of dibasic calcium phosphate on the dissolution profile was studied. Analysis of dissolution profile on the basis of Higuchi’s model suggested that the drug release mechanism basically swelling and diffusion controlled.

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Description

Pseudoephedrine is a decongestant (sympathomimetic). It works by narrowing the blood vessels to decrease swelling and congestion.If you are self-treating with this medication, it is important to read the manufacturer’s package instructions carefully so you know when to consult your doctor or pharmacist. (See also Precautions section.)

1S,2S)-(+)-Pseudoephedrine condenses with N,N-diisopropyl-2-formyl-1-naphthamide to form the corresponding oxazolidine derivative as a single diasterisomer.[1]

(1S,2S)-(+)-Pseudoephedrine may be used as a chiral auxillary in asymmetric synthesis of enantioenriched organic compounds.[2] It may also be used to prepare a novel tertiary pseudo C2-symmetric 1,2-diamine, which facilitates the enantioselective addition of methyl lithium to imines with better yield.[3]

Pseudoephedrine is a decongestant (sympathomimetic). It works by narrowing the blood vessels to decrease swelling and congestion.If you are self-treating with this medication, it is important to read the manufacturer’s package instructions carefully so you know when to consult your doctor or pharmacist. (See also Precautions section.)

These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).If you are taking the over-the-counter product to self-treat, read all directions on the product package before taking this medication. If you have any questions, ask your doctor or pharmacist. If your doctor has prescribed this medication, take it as directed.

Take this medication by mouth with or without food, usually every 12 or 24 hours, depending on the product or as directed by your doctor or the product package. Do not take more than 240 milligrams in a day. Dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this drug more often than directed. Do not take more of this medication than recommended for your age.If you are using the suspension (liquid), shake the bottle well before each dose. Use a medication-measuring device or spoon to carefully measure the dose. Do not use a household spoon because you may not get the correct dose.Take the capsules or tablets with a glass of water. Swallow the capsules whole. Do not crush or chew the capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.There are many brands and forms of pseudoephedrine available. Read the dosing instructions carefully for each product because the amount of pseudoephedrine may be different between products. Do not take more pseudoephedrine than recommended.Caffeine can increase the side effects of this medication. Avoid drinking large amounts of beverages containing caffeine (coffee, tea, colas), eating large amounts of chocolate, or taking nonprescription products that contain caffeine.http://globalresearchemvendor.comUse pseudoephedrine exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.Do not give pseudoephedrine to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.Take this medicine with a full glass of water. Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time. You may need to shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.

Antihistamines and intranasal corticosteroids form the mainstay of treatment for allergic rhinitis, with intranasal steroids superior to antihistamines in relieving nasal blockage and most other symptoms.9Allergy guidelines advise that use of topical decongestants, although more effective than oral agents, should be limited to less than 10 days, owing to potential for local irritation and drug-induced rhinitis.10 However, oral pseudoephedrine alone or combined with newer antihistamines has been shown to relieve nasal congestion in seasonal allergic and perennial rhinitis.11

In cold and influenza remedies, pseudoephedrine has been combined with a wide range of other agents, but an analgesic is almost universal — usually paracetamol.An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.

 

 

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